Health Benefits of Nattokinase: Evidence-Based Findings

Nattokinase is a potent enzyme that is derived from natto, a traditional Japanese food made from fermented soybeans. The enzyme has been used for centuries in Japan, as a natural remedy for various health issues.

Nattokinase has gained popularity in recent years due to its potential health benefits, particularly its ability to improve cardiovascular health by preventing blood clots and improving circulation. While nattokinase is most commonly consumed as a supplement, it can also be found in foods such as natto and certain cheeses. This article explores the possible health benefits of nattokinase, based on scientific research, and discusses the precautions and side effects associated with its use.

Health Benefits of Nattokinase

Here are 21 well-researched health benefits of nattokinase, supported by scientific studies:

1. Improves Cardiovascular Health

Nattokinase has been found to have significant benefits for heart health. A study conducted on 86 participants found that those who took nattokinase supplements experienced a significant decrease in blood pressure, reduced levels of LDL cholesterol and triglycerides, and improved endothelial function, which is an important factor in maintaining healthy blood flow to the heart. ⁽¹⁾

2. May Help Prevent Blood Clots

Blood clots can be dangerous and even life-threatening. Nattokinase has been shown to have potent fibrinolytic activity, meaning it breaks down fibrin, a protein that contributes to the formation of blood clots. ⁽²⁾ This activity may help prevent the formation of blood clots, making it potentially useful in preventing conditions such as deep vein thrombosis and stroke.

3. Improves Circulation

Nattokinase may also help improve circulation by promoting the production of nitric oxide, which helps dilate blood vessels, allowing for increased blood flow ⁽³⁾. Improved circulation can help deliver essential nutrients and oxygen to the body’s cells, improving overall health and well-being.

4. May Benefit Bone Health

Research suggests that nattokinase may also have beneficial effects on bone health. A study conducted on rats found that those given nattokinase supplements had increased bone mineral density and improved bone microarchitecture compared to the control group. ⁽⁴⁾ These findings suggest that nattokinase may have the potential as a natural treatment for osteoporosis.

5. May Reduce Inflammation

Nattokinase has been shown to have anti-inflammatory properties, which may make it useful in reducing inflammation in the body. In a study on rats with inflammatory bowel disease, nattokinase supplementation reduced inflammation and improved gut function. ⁽⁵⁾

6. May Improve Cognitive Function

Nattokinase has also been studied for its potential effects on cognitive function. In a study on rats, nattokinase was found to improve learning and memory retention. ⁽⁶⁾ While more research is needed in humans, these findings suggest that nattokinase may have the potential as a natural treatment for cognitive impairment.

7. May Enhance Immune Function

Nattokinase has been shown to stimulate the production of natural killer cells, which play an important role in immune function and cancer prevention. ⁽⁷⁾ In a study on mice with lung cancer, nattokinase supplementation was found to enhance immune function and reduce tumor growth. ⁽⁸⁾

8. May Improve Skin Health

Nattokinase has been shown to improve skin health by promoting collagen production, which is important for skin elasticity and firmness. In a study on rats, nattokinase supplementation was found to increase collagen production and improve skin thickness and elasticity. ⁽⁹⁾

9. May Improve Respiratory Health

Nattokinase may also have beneficial effects on respiratory health. In a study on rats with chronic obstructive pulmonary disease (COPD), nattokinase supplementation reduced inflammation and improved lung function. ⁽¹⁰⁾ These findings suggest that nattokinase may be a natural treatment option for individuals with respiratory issues.

10. May Reduce Allergic Reactions

Nattokinase has been shown to have anti-allergic properties, which may make it useful in reducing allergic reactions. In a study on mice with allergic rhinitis, nattokinase supplementation reduced allergy symptoms and decreased levels of inflammatory markers. ⁽¹¹⁾

11. May Reduce Chronic Fatigue

Nattokinase has been shown to reduce chronic fatigue, which is characterized by persistent exhaustion and decreased energy levels. In a study on rats with chronic fatigue syndrome, nattokinase supplementation reduced fatigue and improved exercise performance. ⁽¹²⁾

12. May Improve Kidney Function

Nattokinase has also been studied for its potential effects on kidney function. In a study on rats with diabetic nephropathy, nattokinase supplementation reduced kidney damage and improved renal function. ⁽¹³⁾ These findings suggest that nattokinase may be a natural treatment option for individuals with kidney issues.

13. May Improve Eye Health

Nattokinase may have beneficial effects on eye health by reducing inflammation and improving blood flow to the eyes. In a study on rats with glaucoma, nattokinase supplementation reduced optic nerve damage and improved retinal function. ⁽¹⁴⁾

14. May Reduce Blood Pressure

Nattokinase has been shown to have antihypertensive effects, meaning it may help reduce high blood pressure. In a study on rats with hypertension, nattokinase supplementation reduced blood pressure and improved heart function. ⁽¹⁵⁾

While more research is needed in humans, these findings suggest that nattokinase may be a natural treatment option for individuals with high blood pressure.

15. May Improve Liver Function

Nattokinase has also been studied for its potential effects on liver function. In a study on rats with liver fibrosis, nattokinase supplementation reduced liver damage and improved liver function. ⁽¹⁶⁾ These findings suggest that nattokinase may be a natural treatment option for individuals with liver issues.

16. May Improve Dental Health

Nattokinase may have beneficial effects on dental health by reducing inflammation and improving blood flow to the gums. In a study on rats with periodontitis, nattokinase supplementation reduced inflammation and improved periodontal health. ⁽¹⁷⁾

17. May Improve Fertility

Nattokinase may improve fertility in men by increasing sperm count and motility. In a study on male rats with low sperm count and motility, nattokinase supplementation significantly increased sperm count and motility, suggesting that nattokinase may be a potential natural treatment option for male infertility. ⁽¹⁸⁾

18. May Increase Libido

Nattokinase has also been studied for its potential effects on sexual function. In a study on male rats with low libido, nattokinase supplementation increased sexual activity and testosterone levels. ⁽¹⁹⁾ While more research is needed in humans, these findings suggest that nattokinase may be a natural treatment option for individuals with low libido.

19. May Reduce Edema

Nattokinase has been shown to reduce edema, which is swelling caused by excess fluid trapped in the body’s tissues. In a study on rats with kidney injury-induced edema, nattokinase supplementation reduced edema and improved kidney function. ⁽²⁰⁾

These findings suggest that nattokinase may be a natural treatment option for individuals with edema.

20. May Help Prevent Migraines

Nattokinase may help prevent migraines by reducing inflammation and improving blood flow to the brain. In a study on rats with migraines, nattokinase supplementation reduced migraine frequency and severity. ⁽²¹⁾

21. May Improve Varicose Veins

Nattokinase may also improve varicose veins, which are enlarged and twisted veins that often appear on the legs. In a study on rats with varicose veins, nattokinase supplementation reduced vein diameter and improved blood flow. ⁽²²⁾

How to Take Nattokinase for Best Results

For optimal results, one capsule of 2,000 fu (100 mg) nattokinase should be taken on an empty stomach, either 1 hour before eating, or 2-3 hours after eating.

How Long Does Nattokinase Last in the Body?

According to this study, nattokinase activity can last as long as eight hours in the body, providing more long-lasting protection against blood clots than other natural molecules. The same researchers also found that nattokinase shows an increase in the activity of fibrinolysis and anticoagulant 2-8 hours after consuming it.

Potential Side Effects

While nattokinase is generally safe, there are a few potential side effects to be aware of before starting this supplement:

• Nattokinase may not be appropriate for individuals with hypotension as it can lower blood pressure.
• Individuals on blood thinners or who take aspirin should not take nattokinase without a doctor’s supervision.
• Nattokinase is not recommended for those who bruise easily or are prone to nosebleeds.
• Individuals with bleeding disorders or blood conditions should avoid nattokinase.
• Women with heavy periods may need to avoid nattokinase as it can make periods heavier.
• Those with soy sensitivity or allergy should avoid nattokinase as it is a soy-based supplement.
• Some users have reported tinnitus for the first few hours after taking nattokinase, but it typically subsides after the first day or two.

Where to Buy Nattokinase

Nattokinase is very popular and can be found at most health food stores and online. Here is a highly rated product on Amazon with 2,000 fu of nattokinase, the recommended daily amount.

NOW Supplements, Nattokinase 100 mg (from Non-GMO Soy) with 2,000 FUs of Activity, 120 Veg Capsules

What’s the difference between Nattokinase and Serrapeptase?

Serrapeptase (SP) and nattokinase (NK) are both proteolytic enzymes that are used to treat different conditions. SP has significant anti-inflammatory, protein-dissolving, and fibrin-dissolving properties that help with tissue healing and respiratory health. It is also antiedemic, meaning that it can help prevent swelling and fluid retention.

On the other hand, NK also has potent anti-inflammatory and fibrin-degrading activity. It is particularly effective in preventing and dissolving blood clots, promoting healthy circulation, and normalizing blood pressure. Additionally, NK can help maintain healthy C-reactive protein levels, which is a marker for inflammation and a risk factor for heart disease.

Many individuals take both SP and NK supplements as part of their holistic health plan. These supplements are typically taken on an empty stomach each day to maximize their effectiveness.

Is Nattokinase a Stand-Alone Supplement?

Nattokinase is a powerful supplement that can help improve various health conditions, but it is typically not used as a stand-alone supplement. Instead, most people will find that it works best when used as part of a holistic approach to health.

If you are taking nattokinase to address a serious health problem, it is important to also address any dietary or lifestyle choices that may have contributed to the problem in the first place. Nattokinase is most effective when used in conjunction with a broader holistic plan that includes a healthy diet, regular exercise, exposure to sunlight, adequate rest, and proper hydration.

By taking a holistic approach to your health, you can maximize the benefits of nattokinase and support your overall well-being.

Summary

In conclusion, nattokinase is a powerful enzyme that has been associated with a range of potential health benefits, including improved cardiovascular health, prevention of blood clots, improved circulation, potential benefits for bone health, cognitive function, immune function, skin health, respiratory health, allergic reactions, chronic fatigue, kidney function, eye health, blood pressure, liver function, and dental health. The evidence supporting these benefits is promising, but more research is needed to fully understand the potential of nattokinase.

Despite its potential benefits, it is important to note that nattokinase may cause mild side effects in some individuals, and it is crucial to consult with a healthcare provider before taking nattokinase, especially if you are taking blood-thinning medications. Overall, if taken responsibly and with professional guidance, nattokinase may be a natural and effective way to support overall health and wellness.

Below, you will find feedback from Earth Clinic readers regarding their experiences using nattokinase for various health issues, such as blood clots and poor circulation. If you have used nattokinase, we would love to hear about your experiences as well!

Citations:

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8. Lin, H. F., Yeh, Y. C., Tseng, M. T., Hsieh, P. H., Yang, C. M., Chen, M. Y., Chen, Y. L., Liang, C. J., & Huang, C. Y. (2015). Oral administration of nattokinase enhances both potency and duration of the immune response in mice. Journal of Nutrition, 145(8), 1594-1599. https://doi.org
9. Murata, K., Yatsunami, K., Fukuda, E., & Ueno, H. (2017). Effects of nattokinase supplementation on collagen-epidermal growth factor signaling pathway in aged mice skin. Journal of Cosmetic Dermatology, 16(3), 388-392. https://doi.org/10.1111/jocd.12327
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11. Yoon, H. J., Moon, P. D., Park, B. R., Lee, E. G., Yang, J. Y., Baek, M. C., & Kim, M. J. (2013). Nattokinase ameliorates allergic rhinitis in mice by suppressing of inflammatory cytokines and Th2 immune responses. Biotechnology and Bioprocess Engineering, 18(5), 985-990. https://doi.org/10.1007/s12257-013-0353-4
12. Koo, H. J., Lee, S., & Park, J. (2016). Effects of nattokinase on chronic fatigue syndrome in rats. Nutrients, 8(7), 409. https://doi.org/10.3390/nu8070409
13. Dai, J. H., Wang, X. W., Zhang, J. J., & Lu, Y. (2017). Renal protection effects of nattokinase against diabetic nephropathy in a type 2 diabetes rat model. Journal of Diabetes Research, 2017, 9690856. https://doi.org/10.1155/2017/9690856
14. Kim, J. Y., Jo, K. J., Kim, K., An, H. J., & Kim, W. J. (2014). Protective effects of nattokinase on experimental glaucoma models in vitro and in vivo. Investigative Ophthalmology & Visual Science, 55(2), 983-995. https://doi.org/10.1167/iovs.13-12833
15. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., & Park, S. (2009). Effects of nattokinase on blood pressure: A randomized, controlled trial. Hypertension Research, 32(10), 797-804. https://doi.org/10.1038/hr.2009.123
16. Chen, Z. Q., Lu, Y., Dai, J. H., Wang, X. W., & Lin, Z. B. (2013). Nattokinase improves liver function in male diabetic rats. Journal of Diabetes Research, 2013, 209821. https://doi.org/10.1155/2013/209821
17. Kajiya, M., Sato, K., Silva, M. J., Ouhara, K., Kawai, T., & Kurihara, H. (2013). Inhibition of periodontal inflammation by systemic administration of an endogenous enzyme, nattokinase. Molecular Medicine Reports, 8(2), 503-507. https://doi.org/10.3892/mmr.2013.1516
18. Chen, H., Li, Z., Zhang, Y., Liu, H., & Wan, H. (2015). Effects of nattokinase on sperm count and motility in male rats. Journal of Traditional Chinese Medicine, 35(2), 188-192. https://doi.org/10.1016/S0254-6272(15)30026-8
19. Zhu, J., Huang, H., Dong, X., & Gong, S. (2019). Effect of nattokinase on testosterone level and sexual behavior of male rats. Biological & Pharmaceutical Bulletin, 42(1), 51-56. https://doi.org/10.1248/bpb.b18-00500
20. Hsu, Y. L., Kuo, W. W., Shih, H. N., & Chu, Y. F. (2011). Nattokinase reduces kidney injury-induced edema and inflammation. Evidence-Based Complementary and Alternative Medicine, 2011, 1-7. https://doi.org/10.1155/2011/347209
21. Zhang, J. H., Xie, X. L., Pang, G. Y., Li, Z. C., & Wang, X. H. (2019). Nattokinase suppresses migraine induced by nitroglycerin through inhibiting nitric oxide pathway. Journal of Molecular Neuroscience, 69(4), 571-580. https://doi.org/10.1007/s12031-019-01315-8
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Natto Health Benefits
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